Robert Shorr Selected Research

devimistat

1/2022	Evidence for a novel, effective approach to targeting carcinoma catabolism exploiting the first-in-class, anti-cancer mitochondrial drug, CPI-613.
9/2014	Translational assessment of mitochondrial dysfunction of pancreatic cancer from in vitro gene microarray and animal efficacy studies, to early clinical studies, via the novel tumor-specific anti-mitochondrial agent, CPI-613.
11/2011	Non-redox-active lipoate derivates disrupt cancer cell mitochondrial metabolism and are potent anticancer agents in vivo.
8/2011	Formation and anti-tumor activity of uncommon in vitro and in vivo metabolites of CPI-613, a novel anti-tumor compound that selectively alters tumor energy metabolism.

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Robert Shorr Research Topics

Disease

6	Neoplasms (Cancer) 01/2022 - 03/2008
2	Pancreatic Neoplasms (Pancreatic Cancer) 09/2014 - 11/2011
1	Carcinoma (Carcinomatosis) 01/2022
1	Mitochondrial Diseases (Mitochondrial Disease) 09/2014
1	Kaposi Sarcoma (Kaposi's Sarcoma) 08/2011
1	Acquired Immunodeficiency Syndrome (AIDS) 08/2011
1	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 08/2011
1	Breast Neoplasms (Breast Cancer) 08/2011

Drug/Important Bio-Agent (IBA)

4	devimistatIBA 01/2022 - 08/2011
2	Pharmaceutical PreparationsIBA 01/2022 - 08/2011
2	LipidsIBA 01/2022 - 03/2008
1	Fatty Acids (Saturated Fatty Acids)IBA 01/2022
1	Tricarboxylic AcidsIBA 01/2022
1	Cyclin D3IBA 09/2014
1	Gemcitabine FDA Link 09/2014
1	PlacebosIBA 09/2014
1	Proteins (Proteins, Gene)FDA Link 11/2011
1	Antineoplastic Agents (Antineoplastics)IBA 11/2011
1	Paclitaxel (Taxol)FDA LinkGeneric 08/2011
1	Excipients (Suspending Agents)IBA 03/2008

Therapy/Procedure

1	Intraperitoneal Injections 09/2014
1	Therapeutics 09/2014
1	Injections 03/2008
1	Drug Therapy (Chemotherapy) 03/2008